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4fpd

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IUPAC: 1-(4-fluorophenyl)-2-(methylamino)pentan-1-one (4-FPD) hydrochloride

Class of drugs: Cannabinoids; Synthetic cathinones

InChI String: InChI=1S/C12H16FNO/c1-3-4-11(14-2)12(15)9-5-7-10(13)8-6- 9/h5-8,11,14H,3-4H2,1-2H3

CFR: Not Scheduled (12/2019)

CAS# Not Available

Synonyms: 4-Fluoro Pentedrone, 4-Fluoro-α-Methylamino-Valerophenone, 4-FPD

Source: Department of Homeland Security

Appearance: Tan Solid Material

Synthetic cathinones are a broad group of “designer drugs“. Biological effects of their action are similar to those caused by amphetamine or cocaine. They are marketed either as collectibles (“not suitable for human consumption”) or as “research chemicals”. Synthetic cathinones are akin to amphetamines, and the only difference between synthetic cathinones and the respective amphetamines is the presence of a carbonyl group in the β-position with respect to the amino group in cathinone derivatives.

 

For this reason, synthetic cathinones are called bk-amphetamines. Since cathinone is a β-keto derivative of amphetamine, it stimulates and shows sympathomimetic action upon the central nervous system. The action of cathinone and its derivatives relies mainly on inhibiting reuptake of neurotransmitters; this results in their increased concentration in the inter-synaptic space and stronger activation of cathinone-sensitive receptors. Additionally, relatively strong inhibitory actions of cathinone derivatives towards monoamine oxidase (MAO) and higher selectivity of the cathinone derivatives toward MAO-B isoenzyme have been reported.

 

Inhibition of the isoenzyme, normally metabolizing dopamine, prevents degradation of the important neurotransmitter. It can be assumed that synthetic cathinones show affinity towards monoamine transporters responsible for endogenous amines, such as serotonin or dopamine, by increasing their concentration in inter-synaptic space.

 

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