5F-ADB is also known as 5F-MDMB-PINACA or 5F-ADB-PINACA. However, it is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family. It is used as an active ingredient in synthetic cannabis products and is sold online as a designer drug. 5F-ADB is a potent agonist of the CB1 receptor. However, its unclear whether it is selective for this target.
5F-ADB was first identified in November 2014. This product is extremely potent based on the very low levels detected in tissue samples. Also, it appears to be significantly less toxic than earlier synthetic cannabinoid drugs that had previously been sold.
In 2018, it was the most common synthetic cannabinoid to be identified in Drug Enforcement Administration seizures. 5F-ADB was also identified in cannabidiol (CBD) products from a US-based CBD manufacturer in 2018.