What is 4-AcO-DMT?
4-AcO-DMT—also known as O-acetylpsilocin, 4-acetoxy-DMT, psilacetin, or “synthetic mushrooms”—is a semi-synthetic research chemical in the tryptamine family. This also includes the classic psychedelics like DMT and psilocybin. 4-AcO seems to be very closely related to the magic mushroom compounds psilocybin and psilocin, and like psilocybin. It is speculated to break down into psilocin in the body during first pass metabolism. In fact, 4-AcO-DMT was first synthesized in the early 1960s by Albert Hofmann, the same chemist who discovered LSD and first synthesized psilocybin. As an employee for the pharmaceutical company Sandoz, Hofmann and his colleague, Franz Troxler, were playing around with molecules similar to psilocin, and patented psilacetin along with four other esters (organic compounds that react to water by producing alcohol) of psilocin in 1963.
Before I start to explain what the 4-AcO trip is like, it’s important to emphasize just how dose-dependent the research chemical is. The general consensus among users on message boards and the nine people who filled out a survey I created on 4-AcO, is that lower doses feel like a psilocybin experience, while higher doses start to more so resemble a DMT experience. Or as Sarah*, one of my survey participants, put it, “It was like mushrooms, DMT, and acid in one… like a long DMT trip with the warm and loving feeling of mushrooms, and the mind-blowing experience of acid.”
4-ACO Dose Ranges for Oral Ingestion:
- Microdose: 2.5 – 5 mg
- Low Dose: 5 – 10 mg
- Moderate Dose: 10 – 20 mg
- High Dose: 20 – 40 mg
- Heroic Dose: 40 mg +
As a general reference point, many say that oral doses of 4-ACO-DMT in the 15 to 20 mg range greatly resemble a 3.5-gram magic mushroom experience. And with all new psychedelics, it’s best to start with a low to moderate dose, or even microdose, for your first trip in order to get a lay of the land before diving into stronger experiences.