4-Hydroxy-N-methyl-N-isopropyltryptamine (also known as 4-HO-MiPT, and Miprocin) is a novel psychedelic substance of the tryptamine class. It produces psilocybin-like psychedelic effects when administered. It is part of a series of psychedelic substituted tryptamines such as 4-AcO-DMT, 4-HO-MET, 4-HO-DiPT. They are considered to produce variations of the core psychedelic effects typified by psilocin.
This substance is relatively uncommon and has only a short history of human use. Alexander Shulgin evaluated its activity in humans in 1979. Interestingly, describing a trial of 12mg as a richly insightful and highly erotic experience. A description of 4-HO-MiPT is included in Shulgin’s 1997 book TiHKAL. Shulgin’s trials and other anecdotal reports suggest that 4-HO-MiPT is similar in activity to psilocin, the active component in psilocybin mushrooms.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MiPT in humans. As with psilocin, there have been no reported deaths from 4-HO-MiPT use. Despite the existence of reports of people taking doses which far exceeds the active dose. This suggests its well-tolerated physiologically.
- Sedation & Stimulation
- Spontaneous physical sensations
- Changes in felt bodily form
- Changes in felt gravity
- Temperature regulation suppression
- Muscle contractions
- Olfactory hallucination
- Frequent urination
- Pupil dilation
- Increased salivation
- Excessive yawning
- Watery eyes
- Teeth grinding
The toxicity and long-term health effects of recreational 4-HO-MiPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-MiPT is a research chemical with very little history of human usage.
Similarly, anecdotal evidence from those have tried 4-HO-MiPT suggests no negative health effects. attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Tolerance and addiction potential
4-HO-MiPT is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
4-HO-MiPT presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-HO-MiPT all psychedelics will have a reduced effect.
However, many psychoactive substances are safe on their own. Equally, they can quickly become dangerous or even life-threatening when combined with other substances.