4-HO-MET is a tryptamine psychedelic that has been minimally researched and is primarily sold through the research chemical (RC) and novel psychoactive substance (NPS) market. However, it does have a longer history of use than a lot of RCs, having been subjectively described by the chemist Alexander Shulgin in the 1990s and somewhat widely used since the 2000s.

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What is 4-ho-met

4-HO-MET is a lesser-known psychedelic drug. It is the 4-hydroxyl analogue of MET. 4-HO-MET was first synthesized by Alexander Shulgin

This substance is chemically similar to the natural occurring psilocin (4-hydroxy-N, N-dimethyltryptamine,
4-HO-DMT) (Figure 1), found among psychoactive fungi in the genus Psilocybe, Panaeolus and others (Passi,
Seifert, Schneider, & Emrich, 2002) together with psilocybin (Figure 1). The effects of 4-HO-MET are described by Shulgin as similar to psilocin

Where to buy 4-ho-met

4-HO-MET and other tryptophan derivatives are sold online with our shop being one of the most trusted on the internet. We receive huge retail and wholesale commands from around europe asia, the pacifics and the USA. We discretely package and ship to our clientsin all confidentiality and safety. For more information you can contact our customer care following the link below .

Pharmacological effects

Very little is known about these new compounds, which are rarely the subject of studies on either humans or
animals. Therefore, no one really knows about long-term effects, dependency potential, toxicological risks, or possible contraindications.

It is known for producing less mentally intense, though highly visual experiences relative to psychedelics like LSD, psilocin, and 4-AcO-DMT. That is a fair general characterization of the drug, but its tendency to be recreational and clearheaded should not be overstated. Some users experience strong mental effects at common doses and for a large portion of users it will eventually become intense if high enough doses are used. As is true for essentially all psychedelics, it deserves respect and should not be treated as a risk-free substance. A proper set and setting remain important factors for reducing the risks and enhancing the positive aspects of the drug.



Systematic chemical name
Other names
None known.
Other chemical names and variants
tryptamine, n-ethyl-4-hydroxy-n-methyl; 4-indolol, 3-[2-(ethylmethylamino)ethyl]; nethyl-4-hydroxy-n-methyltryptamine; 3-[2-(ethylmethylamino)ethyl]-4-indolol
Chemical Abstracts Service (CAS) registry number
Molecular information
Formula: C13H18N2O
Weight: 218 g/mol
Synthesis, manufacture and precursors
4-acetoxyindole as the main precursor; oxalylchloride; methylamine: ethylamine;
Physical description
White powder/crystals

Effects of 4-ho-met


  • Open eye visuals (OEVs) and Closed eye visuals (CEVs)
  • Easygoing headspace
  • Mood improvement and euphoria
  • Increased sense of humor and Laughter
  • Minimal anxiety
  • Music enhancement
  • Light to moderate entactogenic effects (e.g. increased appreciation and sense of connection)
  • Auditory hallucinations
  • Minimal bodyload
  • Increased sociability
  • Pleasurable body high (e.g. warm and/or tingling sensations


  • GI distress (e.g. stomachache, nausea, indigestion)
  • Anxiety and panic
  • Confusion
  • Uncomfortable comeup or comedown
  • Paranoia
  • Cold sensations
  • Thought loops
  • Sweating
  • Sensation of overheating
  • Bodily heaviness (i.e. perception of your body being heavier)
  • Increased heart rate and blood pressure

Legality  of 4-ho-met

Belgium: non-controlled
Bulgaria: non-controlled
Finland: controlled
Hungary: controlled
Lithuania: controlled
Portugal: controlled
Slovakia: controlled
Sweden: controlled

Additional information


10g, 50g, 100g, 500g, 1000g


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