What is u-48800
The NSO u-48800 [trans‐2‐(2,4‐dichlorophenyl)‐N‐2‐(dimethylamino)cyclohexyl)‐N‐methylacetamide, monohydrochloride] appeared in 2017 for the first time on the market. Together with its regioisomer U‐51754 (methene‐U‐47700), which was also described as an NSO. It belongs to the so‐called U‐drugs and is structurally non‐related to classical opioids as morphine and fentanyl. u-48800 receptor affinity studies were not yet performed, but based on the analogy to U‐51754, comparable pharmacological effects are likely.
Due to a higher affinity to the κ‐receptor in comparison to the μ‐receptor, analgesia with fewer unwanted pharmacological effects. Respiratory depression could be expected. Solimini et al recently reviewed the pharmacotoxicology of non‐fentanyl‐derived NSOs. This found u-48800 available as a “research chemical”; of the opioid analgesic class to replace U‐47700 and that conventional drug tests do not detect such compounds. Due to the growing number of acute intoxication cases, they encouraged pharmacological, toxicological, and forensic research on these compounds to provide effective detection methods, amongst others.
What does u-48800 do?
Similar to opioids, cannabinoids produce their effects by interacting with specific receptors, located within different parts of the CNS. Simply put, cannabinoids regulate how cells communicate – how they send, receive, or process messages.