5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT, ‘foxy’) is one of the most popular tryptamine hallucinogens in the illicit drug market. It produces serious adverse effects, but its pharmacological profile is not well recognized. In vitro data have shown that 5-MeO-DIPT acts as a potent serotonin transporter (SERT) inhibitor and displays high affinity at serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors. In this study, using microdialysis in freely moving rats, we examined the effect of 5-MeO-DIPT on dopamine (DA), serotonin (5-HT), and glutamate release in the rat striatum, nucleus accumbens, and frontal cortex. In search of a possible neurotoxic effect of 5-MeO-DIPT, we measured DA and 5-HT tissue content in the above rat brain regions and also determined the oxidative DNA damage with the comet assay.

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5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) a synthetic oral active hallucinogenic tryptamine derivative.  Similarly, also called Foxy or Foxy methoxy.

Clinical data indicated potent multi-organ effects of 5-MeO-DIPT.  However, users experienced euphoria, disinhibition, increased sociability, visual, and auditory hallucinations.  In addition, effects like mioclonus, restlessness, insomnia and anxiety, nausea, vomiting, and diarrhea have been experienced.

Cognitive deficits observed in animals possible toxicity of 5-MeO-DIPT. Suggested by in some behavioral tests.   injected repeatedly to adolescent rats showed deleterious effects on learning and memory in adulthood

Currently, there exist over a hundred types of synthetic drugs and research chemical compounds. with slightly altered forms to escape detection from the DEA and other government regulatory bodies. 5-MeO-DIPT In 2012, The Synthetic Drug Abuse Prevention Act was passed, which put many of the synthetic drugs into Schedule One classification. Schedule One drugs  are substances that are abused and induce a high, that are dangerous, addictive, and have no medical purpose or value.  More than 500 synthetic drugs identified in 2015,. Synthetic drugs and research chemicals abused today include both stimulant-type substances and synthetic cannabinoids (5-meo-dipt).

Though mind-altering, it doesn’t make safe to use. Synthetic drugs are  potent and powerful than the original drugs they emulate. Synthetic drugs contain different chemicals not tested for human consumption. These drugs can have several adverse effects on users and also come with a risk of addiction. Yearly, synthetic and research chemical drug abuse account for about 1000 hospitalization. and dozens will die from their effects.

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