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DCK or 2′-Oxo-PCM (deschloroketamine) O-PCM, DXE. However, it is a lesser-known novel dissociative substance of the arylcyclohexylamine class.  Interestingly, it produces dissociative, anesthetic and hallucinogenic effects when administered.

Early discussion over DCK has revolved around speculation over claims of antibacterial or immunosuppressant properties. If this speculation is valid, it is possible that its prolonged use could potentially pose a serious threat. Thus, misuse of this substance is highly discouraged and caution to avoid treating it like its parent compound, ketamine.

2′-Oxo-PCM has recently become easily accessible through online research chemical vendors .

Very little data exists about the pharmacological properties, metabolism, and toxicity of O-PCM. Also, it has a very brief history of human usage. Strongly recommend the use of harm reduction practices.


Equally, Deschloroketamine, or 2-Phenyl-2-(methylamino)cyclohexanone, is classed as an arylcyclohexylamine drug. Besides, Descholoroketamine contains a phenyl ring bonded to a cyclohexane ring substituted with an oxo group (cyclohexanone).


Pharmacology of DCK

Further information: NMDA receptor antagonist

Morever, Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as 3-MeO-PCP, PCP and MXE. NMDA receptors, a type of glutamate receptor, allow for excitatory electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives inactivate the NMDA receptors by blocking them. This disconnection of neurons leads to the general loss of bodily sensation, motor coordination, memory recall and eventually this substance’s equivalent of the “k-hole.”


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