LSD usually comes in little paper squares (blotter) which have been soaked in tiny quantities of solution and dried. Microdots contain d-lysergic acid diethylamide as coloured gelatine pieces (gel tabs), tablets or very tiny pills. Once common was the use of sugar cubes which had a drop of LSD solution put on them. Alternatively, users directly drop onto the tongue from a dropper bottle. When dealing with an actual solution, there is a risk of taking much more than intended.

However it comes, users hold it under the tongue and/or chew it. Few people would want to take LSD very regularly.Thus,  people usually take it seriously and treat a trip as an infrequent and special experience.

Sometimes, doses of ‘LSD’ have turned out to be other chemicals such as the NBOMe drugs. This is a serious problem, because taking too much of these is much more dangerous than taking too much LSD, and could even kill.